RAF Typhoon FGR4s have joined forces with France's air force in a joint strike against an subterranean weapons facility in Syria used by the IS group, as stated by the UK's MoD.
The location, located using surveillance, was believed to be housing weapons and explosive materials, the announcement noted, and was situated in hills just north of the ancient city of Palmyra in central Syria.
"Our aircraft utilized laser-guided Paveway IV weapons to hit a series of approach shafts down to the site... preliminary assessments suggest the objective was successfully hit," the ministry announced.
There was no indication of any harm to civilians in the strike late on Saturday and all the aircraft returned safely, the MoD added.
The Typhoon FGR4s were backed up by a Voyager refuelling tanker.
IS - also known as the so-called Islamic State - enforced extremist governance over parts of both Syria and Iraq prior to its 2019 collapse.
"This strike underscores British leadership, and commitment to operate in unison with our allies, to stamp out any re-emergence of IS and their violent and radical beliefs in the region," UK Defence Secretary John Healey said.
British military aircraft have performed patrols over Syria to "deter any attempted resurgence" of Islamic State following its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I extend gratitude to every member of our armed forces who took part in this strike for their skill and their courage," he commented. "They were among thousands of British personnel stationed over Christmas and New Year. This operation, to take out dangerous terrorists who threaten our security, shows how UK forces are ready to step up, throughout the year, ensuring Britain's security domestically and powerful internationally."
In December, the US military carried out what it described as a "major assault" targeting IS targets in the country, after an attack resulted in the deaths of two US servicemembers and a civilian linguist in the Palmyra area.
The United Nations says Islamic State still maintains between 5,000 and 7,000 combatants in Syria and Iraq.